THEORIES OF THE ORIGIN OF vCJD (1)
pre-November 1989 bovine brain was being used for human food manufacture
substantial doses of infectivity entered the human food chain
human oral minimum infectious dose not known, only informed guesses (e.g. assumption of 1g of infected brain regarded as very conservative by some - could be 1kg)
oral route via human food products seems highly likely to be a route for human infection