For making e-services with people and not only with specialists, a new deal and a more concrete vision of innovation is necessary. In Reunion Island, we have introduced Semiotic Web as a human-centred concept for managing sustainable development with ICT (Information and Communication Technologies). Signification or semiosis is the key psychological process that makes sense for practising usage based research and development with people by sharing data, information and knowledge. Living Labs (LL) is the overall conceptual frame that stresses on political and methodological principles for user-driven open innovation. On more pragmatic, scientific and technical aspects, we conceived a LL method based on Sign management and a tool, the Creativity Platform, used for co-designing e-services iteratively with lead-users. These resources have been applied since 10 years at Reunion university for tropical biodiversity management (forests and corals) and instrumental e-learning of music (guitar and piano).