The project iRegions explores how Living Labs can contribute as a tool to cluster development of the three ICT-based clusters CyberForum, Kista Science City and Tartu ICT cluster. Living Labs are looked at from the perspective of the implementation of the open innovation paradigm at cluster level, as well as the emergence of new interaction models between research, business and local authorities for the benefit of companies’ growth and economic development. Sustainable business models for Living Labs shall be at the core of the future activities in the iRegions project.