Geometric model of the Heme binding motif

We have extracted from the Protein Data Bank the coordinates of the motif amino-acids in 9 globins and performed a simultaneous multiple registration and modeling to obtain the following model.

Thick red sticks : computed model (blue / green : two exclusive positions)

Wireframe : original motifs from the 9 globins

The model of the motif is composed of the mean geometric configuration of the amino acids, the covariance on this configuration, and the noise model for the observation of one motif instance. We also add the observation probability of every amino acid and the correlation of this probability between any two amino acids: the two amino acids displayed in blue and green are two exclusive configurations.


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xpennec@sophia.inria.fr