Gallery

Integration
Simulation

Here are some illustrations of our work on coupling electromechanical models of the myocardium with data from XMR Interventional Imaging.

Click on the images to see a bigger version.

Integration of XMR Cardiac Electromechanical Information

Constellation Catheter Measures

The transparent surface is the segmented right ventricle from the cardiac MR image, the sphere is the Constellation catheter, in the RVOT.

Movies

Movie ! Rigid Registration of the Constellation Catheter with the segmented cardiac MRI (7 Mo).

Movie ! Movie of the Normal Heart Beat Sequence followed by the Ectopic Heart Beat Sequence (12 Mo).

Normal Heart Beat Recording Sequence with Constellation Catheter

Normal Heart Beat Recording

Ectopic Beat Recording with Constellation Catheter

Ectopic Heart Beat Recording

ESI System for Electrophysiology Measures

Movies

Movie ! Non-Rigid Registration of the ESI surface with the segmented cardiac MRI (1.5 Mo).

Movie ! Movie of the ESI Electrophysiology Measures, on the surface obtained by registration with the cardiac MR (64 Mo!).

Cardiac Electrophysiology Measures on the MR Derived Surface

ESI Electrophysiology Measures

Simulation of the Cardiovascular Pathologies with the Electromechanical Model of the Heart

Ectopic Heart Beat

Adjustment of the Heart Model to Patient Anatomy

Heart Model in Patient Anatomy

Simulation of Action Potential Propagation during Ectopic Heart Beat

Initialisation of Simulated Ectopic Heart Beat
with Constellation Catheter

Simulated Ectopic Heart Beat Isochrones

Scar and Left Branch Block Simulation

Adjustment of the Heart Model to Patient Anatomy

Heart Model in Patient Anatomy

Positioning of Measuring System from XMR and Integration of Scar from late enhancement MR

ESI measured isochrones
and position of simulated scar (red)

Simulation of Action Potential Propagation and Mechanical Contraction with Left Branch Block and Scar

simulated contraction,
red: depolarised

Forward Previous pictures of the electromechanical model I developed during my PhD can be found here:

Images

Click on images to see larger versions.

Simulated Electrical Propagation Isochrones, same views as the measures from Durrer et al.

Model built from UCSD data

Model built from DTI

Comparison with the in vivo measures from the Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, NIH

NIH in vivo measures
pacing electrodes

NIH in vivo measures

NIH in vivo measures (apex view)

Simulations with the model built from UCSD data

Simulation with UCSD data
simulated pacing electrodes

Simulation with UCSD data

Simulation with UCSD data (apex view)

Simulations with the model built from DTI data

Simulation with DTI data
simulated pacing electrodes

Simulation with DTI data

Simulation with DTI data (apex view)

In Wall comparison between the models built from the UCSD data and from DTI data

Simulation with UCSD data
(in wall view)

Simulation with DTI data
(in wall view)

Simulated Electromechanical Contraction

External view

ElectroMechanical Model
with Action Potential

Transparent View of the Myocardium (green/red lines represent open/closed valves)

Simulated Heart Cycle

Visualisation of the Contraction on the Left Ventricle Endocardium

Left Ventricle Endocardium Deformation
during Simulated Heart Cycle

Quantitative Parameters during Simulation

Rotation for different epicardium points

Epicardium points measured for rotation

Contraction for different epicardium points

3D Image Segmentation with a volumetric deformable biomechanical model

Deformable Biomechanical Model
in a 3D MRI

Electromechanical Model in a 4D Image

Deformable ElectroMechanical Model
in a 4D UltraSound Image

Rotation from: only image, only electromechanical contraction, image+electromechanical contraction

Rotation comparison using images, simulation or both.

Videos

Electrical wave propagation

Isotropic wave (3 Mo)
Slightly anisotropic wave (2.1 Mo)
Very anisotropic wave (2.1 Mo)
Simulating a reentry spiral in a myocardium cube (8.7 Mo)

Electromechanical Coupling

Electrical wave propagation + Mechanical contraction

depolarization wave + contraction + relaxation (3.5 Mo)
depolarization wave + contraction + relaxation (viewpoint up) (4.0 Mo)
contraction + relaxation (left ventricle endocardium surface) (1.0 Mo)

Simulated Cycle (green/red lines represent open/closed valves)

Cycle phases decomposed (3.1 Mo)
Cycle normal speed (5.3 Mo)

Interaction with 3D images

Between the canine heart model and a segmented image of the Visible Man

Global Rigid Transformation (5.7 Mo)
Global Similarity Transformation (1.6 Mo)
Global Affine Transformation (3.7 Mo)
Local Transformation (1.6 Mo)

Between the canine heart model and a human cardiac MRI (rigid -> similarity -> affine -> local deformation)

Along the Y plane (8.9 Mo)
Along the Z plane (21 Mo)
3D View (15 Mo)

Meshes:

Compressed VRML1 files of the beating heart mesh during the simulated cycle (or compressed archive of all the files). Each mesh represents a 0.01 s step of the simulation. These meshes are the volumetric electromechanical model extracted surfaces.
Original myocardium geometry and fiber directions are courtesy of the Cardiac Mechanics Research Group of UCSD.

Remark ? Question ? Missing link ? mail!

maxime.sermesant@inria.fr