{"id":2513,"date":"2023-09-07T16:59:33","date_gmt":"2023-09-07T16:59:33","guid":{"rendered":"http:\/\/localhost:8888\/wordpress\/?page_id=2513"},"modified":"2024-05-05T21:11:53","modified_gmt":"2024-05-05T21:11:53","slug":"2mds","status":"publish","type":"page","link":"http:\/\/localhost:8888\/wordpress\/projects\/2mds\/","title":{"rendered":"MULTISCALE MODELING OF DRAVET SYNDROME"},"content":{"rendered":"\n

2MDS<\/strong><\/h1>\n\n\n\n
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2MDS aims to gather a multidisciplinary team around the issue of certain channelopathies<\/strong>, a group of diseases caused by the dysfunction of ion channels or their interacting protein ions, with a special focus on the Dravet Syndrome<\/strong> (DS) which is associated with a severe form of child epilepsy.
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The group, spread over 3 centers, includes various specialists in mathematical and experimental neuroscience, and Markovian computational modeling:<\/p>\n<\/div><\/div>\n\n\n\n

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LOUISIANE LEMAIRE<\/a><\/u><\/span><\/font>,
post-doc, MathNeuro<\/a> project, Inria branch at the University of Montpellier<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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FABIEN CAMPILLO<\/a><\/u><\/span><\/font> 2MDS PI<\/strong>
MathNeuro<\/a> project, Inria branch at the University of Montpellier<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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PIERRE DEL MORAL<\/a><\/u> 2MDS co-PI<\/strong>
Astral<\/a> project, Inria center at the University of Bordeaux<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n
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JUAN MANUEL ENCINAS<\/u><\/span><\/font> <\/a>, head of the “Laboratory of neural stem cells and neurogenesis<\/a>“, Basque center for neuroscience<\/a>, Bilbao<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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SERAFIM RODRIGUES<\/a><\/u><\/span><\/font>, head of the “Mathematical, Computational and Experimental<\/a>“, Ikerbasque<\/a> & BCAM<\/a>, Bilbao<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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MATHIEU DESROCHES<\/a><\/u><\/span><\/font>, head of the MathNeuro<\/a> project, Inria branch at the University of Montpellier<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n
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The objective of 2MDS is to develop a multiscale computational framework which integrates micro-, meso-, and macro-scale models with new methods of Monte Carlo simulation, in order to study the dynamics of neuronal systems in the context of Dravet syndrome, and to compare our multiscale model with multiscale electrophysiological experiments.<\/p>\n\n\n\n

DS is a severe form of epilepsy which affects children. The majority of the children suffering from DS have a mutation on a specific gene, SCN1A, which codes for the voltage-gated sodium channel \u03b1-subunit NaV1.1. This results in an overactivity of the pyramidal cells (hyperexcitability). The elevated firing of pyramidal cells is a key element of epileptic seizures.<\/p>\n\n\n\n

Several models of DS exist. In 2MDS, we will go beyond our previous work by developing a truly biophysical multiscale model targeted for DS, starting with a Markov model of NaV1.1.<\/p>\n\n\n\n

See the PDF<\/a> for a more detailed presentation of the project.<\/em><\/p>\n\n\n\n

Agenda<\/h2>\n\n\n\n