GIS-PRIONS

Evaluation of MR Spectroscopy and Diffusion Imaging in the Diagnosis of Creutzfeldt-Jakob Disease

Project Aims

The principal objectives of the project are:

to determine the benefit of using multi-modal Magnetic Resonance Imaging (MRI) analysis of the brain, which associates Magnetic Resonance Spectroscopy (MRS) and Diffusion-Weighted MRI, in the diagnosis of the Creutzfeld-Jakob Disease (CJD),
to analyse if such anomalies vary with the type of disease (sporadic, genetic, iatrogen or new-variant).
to study along two subsequent examinations the evolution of anomalies in different types of CJD,
to establish, each time a post-mortem examination of the brain is possible, the correlation between the anomalies observed in multi-modal MRI and in neuropathological data.

The study aims to determine the role of adding MRS to the conventional imaging modalities towards an earlier CJD oriented diagnosis. Some facts to be considered are the metabolic indications of neural destruction in the areas that appear to be normal in conventional imagerie; and possible relevant signs of classification of the different types of CJD.

Partners

Study coordinator:Jean Philippe Brandel
EPIDAURE Research Group, INRIA, Sophia Antipolis - Marius George Linguraru, Nicholas Ayache,Miguel Angel Gonzalez Ballester
CNRS UPR 640 LENA - Didier Dormont, Eric Bardinet
Unit 360, National Institude of Health and Medical Research (INSERM) at La Pitie Salpetriere , Paris - Jean Philippe Brandel, Baptiste Faucheux, Stephane Haik, Jean-Jacques Hauw
The Department of Neuroradiology, La Pitie Salpetriere Hospital , Paris - Didier Dormont, Damien Galanaud
The Centre of Biological and Medical Magnetic Resonance (CRMBM) (UMR 6612, National Centre for Scientific Research (CNRS)), Faculty of Medicine, Marseille - Damien Galanaud, Patrick Cozzone
Raymond Escourolle Neuropathological Laboratory, La Pitie Salpetriere Hospital , Paris - Baptiste Faucheux, Stephane Haik, Jean-Jacques Hauw
The National Reference Cell of CJD, La Pitie Salpetriere Hospital , Paris - Jean Philippe Brande,Stephane Haik

Project Results

the accurate detection of abnormal MR intensities (prompted by the clinicians) in the deep grey nuclei of the brain of CJD patients;
the study of assymetries in CJD MR signal;
the classification of intensities in sporadic CJD FLAIR images with a more significant hypersignal in the caudate nuclei (10/10 cases) and putamen (6/10) than thalami;
the quantification of the higher hyperintensities in the pulvinar of variant CJD patients, even in questionable cases;
the definition of new MR-based measures to differentiate between CJD cases and healthy controls and between sporadic CJD and variant CJD cases;
the quantification of metabolite variantions in spectroscopy data between CJD patients and healthy controls.

Please refer to the following slide for a summary of project results: PPT.

GIS-Prions Publications

M.G. Linguraru, N. Ayache, E. Bardinet, M. A. González Ballester, D. Galanaud, S. Haik, B. Faucheux, J.J. Hauw, P. Cozzone, D. Dormont, J.P. Brandel: Differentiation of sCJD and vCJD Forms by Automated Analysis of Basal Ganglia Intensity Distribution in Multisequence MRI of the Brain - Definition and Evaluation of New MRI-based Ratios. In: IEEE Transactions on Medical Imaging (2006), submitted.

M.G. Linguraru, N. Ayache: Definition and Evaluation of MRI-based for the Neuroradiological Investigation of Creutzfeldt-Jakob Diseases. In: ERCIM News, Special Issue on Biomedical Informatics, Vol. 60 (2005) 52-53. (pdf file)

M.G. Linguraru, N. Ayache, M. A. González Ballester, E. Bardinet, D. Galanaud, S. Haik, B. Faucheux, P. Cozzone, D. Dormont, J.P. Brandel: New Ratios for the Detection and Classification of CJD in Multisequence MRI of the Brain. In: J. Duncan, G.Gerig (eds.) MICCAI 2005, Lecture Notes in Computer Science, Vol. 3750, Springer (2005) 492-499 (pdf file)

D. Galanaud, D. Dormont, J.P. Brandel, M.G. Linguraru, E. Bardinet and J. Chiras: Exploration des Maladies a Prions par IRM Multimodalitaire. In: Journal of Neuroradiology, Special Issue Journees de Neuroradiologie de Langue Francaise 2005, Masson, Vol. 32(2) (2005) 79

S. Haik, D. Galanaud, B.A. Faucheux, N. Privat, M.G. Linguraru, N. Ayache,J.J. Hauw, D. Dormont, J.P. Brandel: Early Diagnosis of Human TSE by Multimodality MRI: Spectrometric Detection of Thalamic Gliosis in a Patient with FFI and Normal FLAIR and Diffusion-Weighted Imaging. In: Proc. of II Symposium on the New Prion Biology: Basic Science, Diagnosis and Therapy, Venice (2005)

M.G. Linguraru, M. A. González Ballester, E. Bardinet, D. Galanaud, S. Haik, B. Faucheux, J.J. Hauw, P. Cozzone, D. Dormont, J.P. Brandel, and N. Ayache. Automated Analysis of Basal Ganglia Intensity Distribution in Multisequence MRI of the Brain - Application to Creutzfeldt-Jakob Disease. Research Report RR-5276, INRIA, 2004.(pdf file)

M.G. Linguraru, D. Galanaud, D. Dormont, B. Faucheaux, S. Haïk, J.J. Hauw, J. Chiras, E. Bardinet, M.A. González Ballester, P. Cozzone, N. Ayache, and J.P. Brandel. Détection et Quantification Automatique des Hypersignaux en IRM dans la Maladie de Creutzfeldt-Jakob. Journal de Radiologie, 85(9):1394, 2004.

M.G. Linguraru, M. A. González Ballester, and N. Ayache. Deformable Atlases for the Segmentation of Internal Brain Nuclei in Magnetic Resonance Imaging. Acta Universitatis Cibiniensis, Technical Series, 2006. Note: To appear.(pdf file)

D. Galanaud, M.G. Linguraru, S. Haïk, D. Dormont, E. Bardinet, B. Faucheaux, P. Cozzone, N. Ayache, and J.P. Brandel. Intérêt de l'IRM Multimodalitaire dand le Diagnostic des Maladies à Prions. In Congrès du G.I.S. Infections à Prions, pages 26, 2004.

M.G. Linguraru, N. Ayache, E. Bardinet, M.A. González Ballester, D. Galanaud, S. Haïk, B. Faucheaux, J.J. Hauw, J. Chiras, P. Cozzone, D. Dormont, and J.P. Brandel. Détection et Quantification Automatique des Hypersignaux en IRM dans la Maladie de Creutzfeldt-Jakob. In Congrès du G.I.S. Infections à Prions, pages 25, 2004.