-
D A Collie.
The role of MRI in the diagnosis of sporadic and variant Creutzfeldt-Jakob disease.
JBR-BTR,
84(4):143-6,
August 2001.
Keywords:
Creutzfeldt-Jakob Syndrome,
pathology,
Human,
Magnetic Resonance Imaging.
| Abstract: |
Creutzfeldt-Jakob disease (CJD) is a rare but important fatal, dementing illness. A number of types of CJD are identified, each with distinct clinical features. Characteristic MRI changes have been described recently. Sporadic CJD, the commonest type, is found worldwide, and causes hyperintensity of the putamen and caudate nuclei. In the recently described variant CJD, which affects younger patients and has been linked to Bovine Spongiform Encephalopathy (BSE) in cattle, a highly characteristic finding of bilateral hyperintensity of the pulvinar nuclei is seen. The MRI features of CJD are reviewed in this article. |
@ARTICLE{collie:jbrbtr:2001,
AUTHOR = {D A Collie},
JOURNAL = {JBR-BTR},
TITLE = {The role of MRI in the diagnosis of sporadic and variant Creutzfeldt-Jakob disease},
YEAR = {2001},
MONTH = {August},
OPTNOTE = {},
NUMBER = {4},
PAGES = {143-6},
VOLUME = {84},
KEYWORDS = {Creutzfeldt-Jakob Syndrome, pathology, Human, Magnetic Resonance Imaging},
ABSTRACT = {Creutzfeldt-Jakob disease (CJD) is a rare but important fatal, dementing illness. A number of types of CJD are identified, each with distinct clinical features. Characteristic MRI changes have been described recently. Sporadic CJD, the commonest type, is found worldwide, and causes hyperintensity of the putamen and caudate nuclei. In the recently described variant CJD, which affects younger patients and has been linked to Bovine Spongiform Encephalopathy (BSE) in cattle, a highly characteristic finding of bilateral hyperintensity of the pulvinar nuclei is seen. The MRI features of CJD are reviewed in this article.}
}
-
D A Collie,
R J Sellar,
M Zeidler,
A C Colchester,
R Knight,
and R G Will.
MRI of Creutzfeldt-Jakob disease: imaging features and recommended MRI protocol.
Clin Radiol,
56(9):726-39,
September 2001.
Keywords:
Clinical Protocols,
Creutzfeldt-Jakob Syndrome,
classification,
Diagnosis Differential,
Human,
Magnetic Resonance Imaging,
methods,
Pulvinar,
pathology,
Support Non-U.S. Gov't,
Thalamus,
pathology.
| Abstract: |
Creutzfeldt-Jakob Disease (CJD) is a rare, progressive and invariably fatal neurodegenerative disease characterized by specific histopathological features. Of the four subtypes of CJD described, the commonest is sporadic CJD (sCJD). More recently, a new clinically distinct form of the disease affecting younger patients, known as variant CJD (vCJD), has been identified, and this has been causally linked to the bovine spongiform encephalopathy (BSE) agent in cattle. Characteristic appearances on magnetic resonance imaging (MRI) have been identified in several forms of CJD; sCJD may be associated with high signal changes in the putamen and caudate head and vCJD is usually associated with hyperintensity of the pulvinar (posterior nuclei) of the thalamus. These appearances and other imaging features are described in this article. Using appropriate clinical and radiological criteria and tailored imaging protocols, MRI plays an important part in the in vivodiagnosis of this disease. |
@ARTICLE{collie:cr:2001,
AUTHOR = {D A Collie and R J Sellar and M Zeidler and A C Colchester and R Knight and R G Will},
JOURNAL = {Clin Radiol},
TITLE = {MRI of Creutzfeldt-Jakob disease: imaging features and recommended MRI protocol},
YEAR = {2001},
MONTH = {September},
OPTNOTE = {},
NUMBER = {9},
PAGES = {726-39},
VOLUME = {56},
KEYWORDS = {Clinical Protocols, Creutzfeldt-Jakob Syndrome, classification, Diagnosis Differential, Human, Magnetic Resonance Imaging, methods, Pulvinar, pathology, Support Non-U.S. Gov't, Thalamus, pathology},
ABSTRACT = {Creutzfeldt-Jakob Disease (CJD) is a rare, progressive and invariably fatal neurodegenerative disease characterized by specific histopathological features. Of the four subtypes of CJD described, the commonest is sporadic CJD (sCJD). More recently, a new clinically distinct form of the disease affecting younger patients, known as variant CJD (vCJD), has been identified, and this has been causally linked to the bovine spongiform encephalopathy (BSE) agent in cattle. Characteristic appearances on magnetic resonance imaging (MRI) have been identified in several forms of CJD; sCJD may be associated with high signal changes in the putamen and caudate head and vCJD is usually associated with hyperintensity of the pulvinar (posterior nuclei) of the thalamus. These appearances and other imaging features are described in this article. Using appropriate clinical and radiological criteria and tailored imaging protocols, MRI plays an important part in the in vivodiagnosis of this disease.}
}
-
A Dervaux,
S Vicart,
F Lopes,
M H Le Borgne,
and Borgne MH Le.
Psychiatric features of vCJD similar in France and UK.
Br J Psychiatry,
178:276,
March 2001.
Keywords:
Adult,
Case Report,
Creutzfeldt-Jakob Syndrome,
diagnosis,
Depressive Disorder,
etiology,
Female,
France,
Great Britain,
Human.
@ARTICLE{dervaux:bjp:2001,
AUTHOR = {A Dervaux and S Vicart and F Lopes and Le Borgne, M H and Borgne MH Le},
JOURNAL = {Br J Psychiatry},
TITLE = {Psychiatric features of vCJD similar in France and UK},
YEAR = {2001},
MONTH = {March},
OPTNOTE = {},
OPTNUMBER = {},
PAGES = {276},
VOLUME = {178},
KEYWORDS = {Adult, Case Report, Creutzfeldt-Jakob Syndrome, diagnosis, Depressive Disorder, etiology, Female, France, Great Britain, Human}
}
-
H C Kim,
K H Chang,
I C Song,
S H Lee,
B J Kwon,
M H Han,
and S Y Kim.
Diffusion-weighted MR imaging in biopsy-proven Creutzfeldt-Jakob disease.
Korean J Radiol,
2(4):192-6,
Oct-Dec 2001.
Keywords:
Adult,
Aged,
Biopsy,
Comparative Study,
Creutzfeldt-Jakob Syndrome,
diagnosis,
Female,
Human,
Magnetic Resonance Imaging,
methods,
Male,
Middle Age,
Retrospective Studies,
Sensitivity and Specificity,
Support Non-U.S. Gov't.
| Abstract: |
OBJECTIVE: To compare conventional and diffusion-weighted MR imaging in terms of their depiction of the abnormalities occurring in Creutzfeldt-Jakob disease. MATERIALS AND METHODS: We retrospectively analyzed the findings of conventional (T2-weighted and fluid-attenuated inversion recovery) and diffusion-weighted MR imaging in four patients with biopsy-proven Creutzfeldt-Jakob disease. The signal intensity of the lesion was classified by visual assessment as markedly high, slightly high, or isointense, relative to normal brain parenchyma. RESULTS: Both conventional and diffusion-weighted MR images demonstrated bilateral high signal intensity in the basal ganglia in all four patients. Cortical lesions were observed on diffusion-weighted MR images in all four, and on fluid-attenuated inversion recovery MR images in one, but in no patient on T2-weighted images. Conventional MR images showed slightly high signal intensity in all lesions, while diffusion-weighted images showed markedly high signal intensity in most. CONCLUSION: Diffusion-weighted MR imaging is more sensitive than its conventional counterpart in the depiction of Creutzfeldt-Jakob disease, and permits better detection of the lesion in both the cerebral cortices and basal ganglia. |
@ARTICLE{kim:kjr:2001,
AUTHOR = {H C Kim and K H Chang and I C Song and S H Lee and B J Kwon and M H Han and S Y Kim},
JOURNAL = {Korean J Radiol},
TITLE = {Diffusion-weighted MR imaging in biopsy-proven Creutzfeldt-Jakob disease},
YEAR = {2001},
MONTH = {Oct-Dec},
OPTNOTE = {},
NUMBER = {4},
PAGES = {192-6},
VOLUME = {2},
KEYWORDS = {Adult, Aged, Biopsy, Comparative Study, Creutzfeldt-Jakob Syndrome, diagnosis, Female, Human, Magnetic Resonance Imaging, methods, Male, Middle Age, Retrospective Studies, Sensitivity and Specificity, Support Non-U.S. Gov't},
ABSTRACT = {OBJECTIVE: To compare conventional and diffusion-weighted MR imaging in terms of their depiction of the abnormalities occurring in Creutzfeldt-Jakob disease. MATERIALS AND METHODS: We retrospectively analyzed the findings of conventional (T2-weighted and fluid-attenuated inversion recovery) and diffusion-weighted MR imaging in four patients with biopsy-proven Creutzfeldt-Jakob disease. The signal intensity of the lesion was classified by visual assessment as markedly high, slightly high, or isointense, relative to normal brain parenchyma. RESULTS: Both conventional and diffusion-weighted MR images demonstrated bilateral high signal intensity in the basal ganglia in all four patients. Cortical lesions were observed on diffusion-weighted MR images in all four, and on fluid-attenuated inversion recovery MR images in one, but in no patient on T2-weighted images. Conventional MR images showed slightly high signal intensity in all lesions, while diffusion-weighted images showed markedly high signal intensity in most. CONCLUSION: Diffusion-weighted MR imaging is more sensitive than its conventional counterpart in the depiction of Creutzfeldt-Jakob disease, and permits better detection of the lesion in both the cerebral cortices and basal ganglia.}
}
-
M Konagaya,
M Sakai,
K Asakura,
Y Matsuoka,
and Y Hashizume.
[T2-weighted MRI and pathological findings in the cerebral hemisphere of panencephalitic Creutzfeldt-Jakob disease].
No To Shinkei,
53(4):398-9,
April 2001.
Keywords:
Brain,
pathology,
Case Report,
Creutzfeldt-Jakob Syndrome,
diagnosis,
Encephalitis,
diagnosis,
Female,
Human,
Magnetic Resonance Imaging,
Middle Age.
@ARTICLE{konagaya:nts:2001,
AUTHOR = {M Konagaya and M Sakai and K Asakura and Y Matsuoka and Y Hashizume},
JOURNAL = {No To Shinkei},
TITLE = {[T2-weighted MRI and pathological findings in the cerebral hemisphere of panencephalitic Creutzfeldt-Jakob disease]},
YEAR = {2001},
MONTH = {April},
OPTNOTE = {},
NUMBER = {4},
PAGES = {398-9},
VOLUME = {53},
KEYWORDS = {Brain, pathology, Case Report, Creutzfeldt-Jakob Syndrome, diagnosis, Encephalitis, diagnosis, Female, Human, Magnetic Resonance Imaging, Middle Age}
}
-
J Koppinen.
The French reflect on BSE.
Aust Vet J,
79(7):452,
July 2001.
Keywords:
Animal,
Animal Feed,
Cattle,
Creutzfeldt-Jakob Syndrome,
prevention & control,
Encephalopathy Bovine Spongiform,
prevention & control,
France,
Human.
@ARTICLE{koppinen:avj:2001,
AUTHOR = {J Koppinen},
JOURNAL = {Aust Vet J},
TITLE = {The French reflect on BSE},
YEAR = {2001},
MONTH = {July},
OPTNOTE = {},
NUMBER = {7},
PAGES = {452},
VOLUME = {79},
KEYWORDS = {Animal, Animal Feed, Cattle, Creutzfeldt-Jakob Syndrome, prevention & control, Encephalopathy Bovine Spongiform, prevention & control, France, Human}
}
-
S L Kraft and P Gavin.
Physical principles and technical considerations for equine computed tomography and magnetic resonance imaging.
Vet Clin North Am Equine Pract,
17(1):115-30,
April 2001.
Keywords:
Animal,
Horse Diseases,
diagnosis,
Horses,
Magnetic Resonance Imaging,
methods,
Tomography X-Ray Computed,
methods.
| Abstract: |
This article discusses how cross-sectional imaging methods such as computed tomography and magnetic resonance imaging can provide unique and diagnostically important information in situations where radiography or diagnostic ultrasound have been unrewarding. |
@ARTICLE{kraft:vcnaep:2001,
AUTHOR = {S L Kraft and P Gavin},
JOURNAL = {Vet Clin North Am Equine Pract},
TITLE = {Physical principles and technical considerations for equine computed tomography and magnetic resonance imaging},
YEAR = {2001},
MONTH = {April},
OPTNOTE = {},
NUMBER = {1},
PAGES = {115-30},
VOLUME = {17},
KEYWORDS = {Animal, Horse Diseases, diagnosis, Horses, Magnetic Resonance Imaging, methods, Tomography X-Ray Computed, methods},
ABSTRACT = {This article discusses how cross-sectional imaging methods such as computed tomography and magnetic resonance imaging can provide unique and diagnostically important information in situations where radiography or diagnostic ultrasound have been unrewarding.}
}
-
D Le Bihan,
Bihan D Le,
J F Mangin,
C Poupon,
C A Clark,
S Pappata,
N Molko,
and H Chabriat.
Diffusion tensor imaging: concepts and applications.
J Magn Reson Imaging,
13(4):534-46,
April 2001.
Keywords:
Brain Diseases,
diagnosis,
Diffusion,
Human,
Image Processing Computer-Assisted,
Magnetic Resonance Imaging,
methods.
| Abstract: |
The success of diffusion magnetic resonance imaging (MRI) is deeply rooted in the powerful concept that during their random, diffusion-driven displacements molecules probe tissue structure at a microscopic scale well beyond the usual image resolution. As diffusion is truly a three-dimensional process, molecular mobility in tissues may be anisotropic, as in brain white matter. With diffusion tensor imaging (DTI), diffusion anisotropy effects can be fully extracted, characterized, and exploited, providing even more exquisite details on tissue microstructure. The most advanced application is certainly that of fiber tracking in the brain, which, in combination with functional MRI, might open a window on the important issue of connectivity. DTI has also been used to demonstrate subtle abnormalities in a variety of diseases (including stroke, multiple sclerosis, dyslexia, and schizophrenia) and is currently becoming part of many routine clinical protocols. The aim of this article is to review the concepts behind DTI and to present potential applications. |
@ARTICLE{lebihan:jmri:2001,
AUTHOR = {Le Bihan, D and Bihan D Le and J F Mangin and C Poupon and C A Clark and S Pappata and N Molko and H Chabriat},
JOURNAL = {J Magn Reson Imaging},
TITLE = {Diffusion tensor imaging: concepts and applications},
YEAR = {2001},
MONTH = {April},
OPTNOTE = {},
NUMBER = {4},
PAGES = {534-46},
VOLUME = {13},
KEYWORDS = {Brain Diseases, diagnosis, Diffusion, Human, Image Processing Computer-Assisted, Magnetic Resonance Imaging, methods},
ABSTRACT = {The success of diffusion magnetic resonance imaging (MRI) is deeply rooted in the powerful concept that during their random, diffusion-driven displacements molecules probe tissue structure at a microscopic scale well beyond the usual image resolution. As diffusion is truly a three-dimensional process, molecular mobility in tissues may be anisotropic, as in brain white matter. With diffusion tensor imaging (DTI), diffusion anisotropy effects can be fully extracted, characterized, and exploited, providing even more exquisite details on tissue microstructure. The most advanced application is certainly that of fiber tracking in the brain, which, in combination with functional MRI, might open a window on the important issue of connectivity. DTI has also been used to demonstrate subtle abnormalities in a variety of diseases (including stroke, multiple sclerosis, dyslexia, and schizophrenia) and is currently becoming part of many routine clinical protocols. The aim of this article is to review the concepts behind DTI and to present potential applications.}
}
-
D Mathews and D H Unwin.
Quantitative cerebral blood flow imaging in a patient with the Heidenhain variant of Creutzfeldt-Jakob disease.
Clin Nucl Med,
26(9):770-3,
September 2001.
Keywords:
Acetazolamide,
pharmacology,
Brain,
pathology,
Case Report,
Cerebrovascular Circulation,
drug effects,
Creutzfeldt-Jakob Syndrome,
diagnosis,
Human,
Magnetic Resonance Imaging,
Male,
Middle Age,
Tomography Emission-Computed Single-Photon,
Xenon Radioisotopes,
diagnostic use.
| Abstract: |
PURPOSE: This report describes quantitative SPECT cerebral blood flow (CBF) changes in a patient with the confirmed Heidenhain variant of Creutzfeldt-Jakob disease. MATERIALS AND METHODS: A 60-year-old man reported visual disturbances, including left hemianopsia. An electroencephalogram, magnetic resonance imaging, cerebral arteriogram, and quantitative SPECT CBF imaging with Xe-133, with and without acetazolamide, were performed. After the patient's death, an autopsy was performed. RESULTS: The electroencephalographic findings were nonspecific, those of magnetic resonance imaging were normal, and the cerebral arteriogram showed minimal atherosclerosis. However, the SPECT scan revealed marked depression of perfusion in the parietal and occipital cortices that did not change with the administration of acetazolamide. Autopsy results were consistent with CJD. CONCLUSIONS: Although there is no consistent pattern of CBF changes that is characteristic of Creutzfeldt-Jakob disease, the Heidenhain variant of that disease may be an exception. Clinical symptoms include profound changes in vision, and the pattern of CBF changes in the patient described here included depression of perfusion in areas of primary and associated visual cortex. Also of interest is the finding that although other imaging did not reveal an abnormality, the CBF changes were marked. In addition, vasoreactivity is poor in response to acetazolamide, a finding that occurs only late in other neuronal degenerative conditions such as Alzheimer's disease. |
@ARTICLE{mathews:cnm:2001,
AUTHOR = {D Mathews and D H Unwin},
JOURNAL = {Clin Nucl Med},
TITLE = {Quantitative cerebral blood flow imaging in a patient with the Heidenhain variant of Creutzfeldt-Jakob disease},
YEAR = {2001},
MONTH = {September},
OPTNOTE = {},
NUMBER = {9},
PAGES = {770-3},
VOLUME = {26},
KEYWORDS = {Acetazolamide, pharmacology, Brain, pathology, Case Report, Cerebrovascular Circulation, drug effects, Creutzfeldt-Jakob Syndrome, diagnosis, Human, Magnetic Resonance Imaging, Male, Middle Age, Tomography Emission-Computed Single-Photon, Xenon Radioisotopes, diagnostic use},
ABSTRACT = {PURPOSE: This report describes quantitative SPECT cerebral blood flow (CBF) changes in a patient with the confirmed Heidenhain variant of Creutzfeldt-Jakob disease. MATERIALS AND METHODS: A 60-year-old man reported visual disturbances, including left hemianopsia. An electroencephalogram, magnetic resonance imaging, cerebral arteriogram, and quantitative SPECT CBF imaging with Xe-133, with and without acetazolamide, were performed. After the patient's death, an autopsy was performed. RESULTS: The electroencephalographic findings were nonspecific, those of magnetic resonance imaging were normal, and the cerebral arteriogram showed minimal atherosclerosis. However, the SPECT scan revealed marked depression of perfusion in the parietal and occipital cortices that did not change with the administration of acetazolamide. Autopsy results were consistent with CJD. CONCLUSIONS: Although there is no consistent pattern of CBF changes that is characteristic of Creutzfeldt-Jakob disease, the Heidenhain variant of that disease may be an exception. Clinical symptoms include profound changes in vision, and the pattern of CBF changes in the patient described here included depression of perfusion in areas of primary and associated visual cortex. Also of interest is the finding that although other imaging did not reveal an abnormality, the CBF changes were marked. In addition, vasoreactivity is poor in response to acetazolamide, a finding that occurs only late in other neuronal degenerative conditions such as Alzheimer's disease.}
}
-
M Matoba,
H Tonami,
H Miyaji,
H Yokota,
and I Yamamoto.
Creutzfeldt-Jakob disease: serial changes on diffusion-weighted MRI.
J Comput Assist Tomogr,
25(2):274-7,
Mar-Apr 2001.
Keywords:
Aged,
Brain,
pathology,
Case Report,
Creutzfeldt-Jakob Syndrome,
diagnosis,
Female,
Human,
Magnetic Resonance Imaging.
| Abstract: |
We present serial changes on diffusion-weighted MRI (DWI) in a patient with Creutzfeldt-Jakob disease (CJD). DWI revealed serial changes of abnormal hyperintense lesions that had become more extensive and conspicuous with progression of neurologic findings, more sensitively than conventional MRI. In the late stage, disappearance of abnormal hyperintense lesions on DWI was observed. DWI proved to be particularly useful for monitoring the progression of CJD. |
@ARTICLE{matoba:jcat:2001,
AUTHOR = {M Matoba and H Tonami and H Miyaji and H Yokota and I Yamamoto},
JOURNAL = {J Comput Assist Tomogr},
TITLE = {Creutzfeldt-Jakob disease: serial changes on diffusion-weighted MRI},
YEAR = {2001},
MONTH = {Mar-Apr},
OPTNOTE = {},
NUMBER = {2},
PAGES = {274-7},
VOLUME = {25},
KEYWORDS = {Aged, Brain, pathology, Case Report, Creutzfeldt-Jakob Syndrome, diagnosis, Female, Human, Magnetic Resonance Imaging},
ABSTRACT = {We present serial changes on diffusion-weighted MRI (DWI) in a patient with Creutzfeldt-Jakob disease (CJD). DWI revealed serial changes of abnormal hyperintense lesions that had become more extensive and conspicuous with progression of neurologic findings, more sensitively than conventional MRI. In the late stage, disappearance of abnormal hyperintense lesions on DWI was observed. DWI proved to be particularly useful for monitoring the progression of CJD.}
}
-
M A Poon,
S Stuckey,
and E Storey.
MRI evidence of cerebellar and hippocampal involvement in Creutzfeldt-Jakob disease.
Neuroradiology,
43(9):746-9,
September 2001.
Keywords:
Brain,
pathology,
Case Report,
Cerebellum,
pathology,
Creutzfeldt-Jakob Syndrome,
diagnosis,
Diagnosis Differential,
Female,
Hippocampus,
pathology,
Human,
Magnetic Resonance Imaging,
Magnetic Resonance Spectroscopy,
diagnostic use,
Middle Age.
| Abstract: |
We report a 51-year-old woman with the Brownell-Oppenheimer (cerebellar) variant of Creutzfeldt-Jakob disease (CJD). She had the typical findings of bilateral basal ganglion changes on MRI, as well as changes in the cerebellum and hippocampus. This case adds further information to the known imaging characteristics of CJD. |
@ARTICLE{poon:neuroradiology:2001,
AUTHOR = {M A Poon and S Stuckey and E Storey},
JOURNAL = {Neuroradiology},
TITLE = {MRI evidence of cerebellar and hippocampal involvement in Creutzfeldt-Jakob disease},
YEAR = {2001},
MONTH = {September},
OPTNOTE = {},
NUMBER = {9},
PAGES = {746-9},
VOLUME = {43},
KEYWORDS = {Brain, pathology, Case Report, Cerebellum, pathology, Creutzfeldt-Jakob Syndrome, diagnosis, Diagnosis Differential, Female, Hippocampus, pathology, Human, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, diagnostic use, Middle Age},
ABSTRACT = {We report a 51-year-old woman with the Brownell-Oppenheimer (cerebellar) variant of Creutzfeldt-Jakob disease (CJD). She had the typical findings of bilateral basal ganglion changes on MRI, as well as changes in the cerebellum and hippocampus. This case adds further information to the known imaging characteristics of CJD.}
}
-
C Poupon,
J Mangin,
C A Clark,
V Frouin,
J Regis,
D Le Bihan,
Bihan D Le,
and I Bloch.
Towards inference of human brain connectivity from MR diffusion tensor data.
Med Image Anal,
5(1):1-15,
March 2001.
Keywords:
Axons,
physiology,
Brain Mapping,
Diffusion,
Human,
Image Processing Computer-Assisted,
Magnetic Resonance Imaging,
methods,
Mathematics,
Nerve Fibers,
physiology.
| Abstract: |
This paper describes a method to infer the connectivity induced by white matter fibers in the living human brain. This method stems from magnetic resonance tensor imaging (DTI), a technique which gives access to fiber orientations. Given typical DTI spatial resolution, connectivity is addressed at the level of fascicles made up by a bunch of parallel fibers. We propose first an algorithm dedicated to fascicle tracking in a direction map inferred from diffusion data. This algorithm takes into account fan-shaped fascicle forks usual in actual white matter organization. Then, we propose a method of inferring a regularized direction map from diffusion data in order to improve the robustness of the tracking. The regularization stems from an analogy between white matter organization and spaghetti plates. Finally, we propose a study of the tracking behavior according to the weight given to the regularization and some examples of the tracking results with in vivo human brain data. |
@ARTICLE{poupon:mia:2001,
AUTHOR = {C Poupon and J Mangin and C A Clark and V Frouin and J Regis and Le Bihan, D and Bihan D Le and I Bloch},
JOURNAL = {Med Image Anal},
TITLE = {Towards inference of human brain connectivity from MR diffusion tensor data},
YEAR = {2001},
MONTH = {March},
OPTNOTE = {},
NUMBER = {1},
PAGES = {1-15},
VOLUME = {5},
KEYWORDS = {Axons, physiology, Brain Mapping, Diffusion, Human, Image Processing Computer-Assisted, Magnetic Resonance Imaging, methods, Mathematics, Nerve Fibers, physiology},
ABSTRACT = {This paper describes a method to infer the connectivity induced by white matter fibers in the living human brain. This method stems from magnetic resonance tensor imaging (DTI), a technique which gives access to fiber orientations. Given typical DTI spatial resolution, connectivity is addressed at the level of fascicles made up by a bunch of parallel fibers. We propose first an algorithm dedicated to fascicle tracking in a direction map inferred from diffusion data. This algorithm takes into account fan-shaped fascicle forks usual in actual white matter organization. Then, we propose a method of inferring a regularized direction map from diffusion data in order to improve the robustness of the tracking. The regularization stems from an analogy between white matter organization and spaghetti plates. Finally, we propose a study of the tracking behavior according to the weight given to the regularization and some examples of the tracking results with in vivo human brain data.}
}
-
J M Smart and A Wood.
Value of fluid-attenuated inversion recovery MR imaging in an unusual case of sporadic Creutzfeldt-Jakob disease.
AJR Am J Roentgenol,
177(4):948-9,
October 2001.
Keywords:
Case Report,
Creutzfeldt-Jakob Syndrome,
pathology,
Human,
Magnetic Resonance Imaging,
methods,
Male,
Middle Age.
@ARTICLE{smart:aajr:2001,
AUTHOR = {J M Smart and A Wood},
JOURNAL = {AJR Am J Roentgenol},
TITLE = {Value of fluid-attenuated inversion recovery MR imaging in an unusual case of sporadic Creutzfeldt-Jakob disease},
YEAR = {2001},
MONTH = {October},
OPTNOTE = {},
NUMBER = {4},
PAGES = {948-9},
VOLUME = {177},
KEYWORDS = {Case Report, Creutzfeldt-Jakob Syndrome, pathology, Human, Magnetic Resonance Imaging, methods, Male, Middle Age}
}
-
A J Thompson,
K J Barnham,
R S Norton,
and C J Barrow.
The Val-210-Ile pathogenic Creutzfeldt-Jakob disease mutation increases both the helical and aggregation propensities of a sequence corresponding to helix-3 of PrP(C).
Biochim Biophys Acta,
1544(1-2):242-54,
January 2001.
Keywords:
Amino Acid Sequence,
Circular Dichroism,
Creutzfeldt-Jakob Syndrome,
genetics,
Isoleucine,
genetics,
Molecular Sequence Data,
Mutation,
Nuclear Magnetic Resonance Biomolecular,
Phosphoprotein Phosphatase,
chemistry,
Protein Structure Secondary,
Support Non-U.S. Gov't,
Valine,
genetics.
| Abstract: |
A peptide corresponding to the third helical region within the PrP(C) protein, from residues 198 to 218 (helix-3), was synthesised with and without the familial 210-Val to Ile Creutzfeldt-Jakob disease mutation. The NMR structure of PrP(C) predicts no global variation in stability for this mutation, indicating that local sequence rather than global structural factors are involved in the pathological effects of this mutation. 1H NMR analysis of peptides with and without this mutation indicated that it had no significant effect on local helical structure. Temperature denaturation studies monitored by CD showed that the mutation increased the helical content within this region (helical propensity), but did not stabilise the helix toward denaturation (helical stability). Aggregation data indicated that, in addition to increasing helical propensity, this mutation increased the aggregation propensity of this sequence. CD and NMR data indicate that helical interactions, stabilised by the Val-210-Ile mutation, may precede the formation of beta-sheet aggregates in this peptide sequence. Therefore, this pathological mutation probably does not facilitate PrP(C) to PrP(Sc) conversion by directly destabilising the helical structure of PrP(C), but may preferentially stabilise PrP(Sc) by facilitating beta-sheet formation within this sequence region of PrP. In addition, helical interactions between helix-3 in two or more PrP(C) molecules may promote conversion to PrP(Sc). |
@ARTICLE{thompson:bba:2001,
AUTHOR = {A J Thompson and K J Barnham and R S Norton and C J Barrow},
JOURNAL = {Biochim Biophys Acta},
TITLE = {The Val-210-Ile pathogenic Creutzfeldt-Jakob disease mutation increases both the helical and aggregation propensities of a sequence corresponding to helix-3 of PrP(C)},
YEAR = {2001},
MONTH = {January},
OPTNOTE = {},
NUMBER = {1-2},
PAGES = {242-54},
VOLUME = {1544},
KEYWORDS = {Amino Acid Sequence, Circular Dichroism, Creutzfeldt-Jakob Syndrome, genetics, Isoleucine, genetics, Molecular Sequence Data, Mutation, Nuclear Magnetic Resonance Biomolecular, Phosphoprotein Phosphatase, chemistry, Protein Structure Secondary, Support Non-U.S. Gov't, Valine, genetics},
ABSTRACT = {A peptide corresponding to the third helical region within the PrP(C) protein, from residues 198 to 218 (helix-3), was synthesised with and without the familial 210-Val to Ile Creutzfeldt-Jakob disease mutation. The NMR structure of PrP(C) predicts no global variation in stability for this mutation, indicating that local sequence rather than global structural factors are involved in the pathological effects of this mutation. 1H NMR analysis of peptides with and without this mutation indicated that it had no significant effect on local helical structure. Temperature denaturation studies monitored by CD showed that the mutation increased the helical content within this region (helical propensity), but did not stabilise the helix toward denaturation (helical stability). Aggregation data indicated that, in addition to increasing helical propensity, this mutation increased the aggregation propensity of this sequence. CD and NMR data indicate that helical interactions, stabilised by the Val-210-Ile mutation, may precede the formation of beta-sheet aggregates in this peptide sequence. Therefore, this pathological mutation probably does not facilitate PrP(C) to PrP(Sc) conversion by directly destabilising the helical structure of PrP(C), but may preferentially stabilise PrP(Sc) by facilitating beta-sheet formation within this sequence region of PrP. In addition, helical interactions between helix-3 in two or more PrP(C) molecules may promote conversion to PrP(Sc).}
}
-
M Zeidler,
D A Collie,
M A Macleod,
R J Sellar,
and R Knight.
FLAIR MRI in sporadic Creutzfeldt-Jakob disease.
Neurology,
56(2):282,
January 2001.
Keywords:
Brain,
pathology,
Creutzfeldt-Jakob Syndrome,
pathology,
Human,
Magnetic Resonance Imaging.
@ARTICLE{zeidler:neurology:2001,
AUTHOR = {M Zeidler and D A Collie and M A Macleod and R J Sellar and R Knight},
JOURNAL = {Neurology},
TITLE = {FLAIR MRI in sporadic Creutzfeldt-Jakob disease},
YEAR = {2001},
MONTH = {January},
OPTNOTE = {},
NUMBER = {2},
PAGES = {282},
VOLUME = {56},
KEYWORDS = {Brain, pathology, Creutzfeldt-Jakob Syndrome, pathology, Human, Magnetic Resonance Imaging}
}