-
S Collins,
A Boyd,
A Fletcher,
M F Gonzales,
C A McLean,
and C L Masters.
Recent advances in the pre-mortem diagnosis of Creutzfeldt-Jakob disease.
J Clin Neurosci,
7(3):195-202,
May 2000.
Keywords:
Biological Markers,
cerebrospinal fluid,
Biopsy,
Brain,
pathology,
Creutzfeldt-Jakob,
Diagnosis Differential,
Electroencephalography,
Human,
Magnetic Resonance Imaging,
Prions,
cerebrospinal fluid,
Support Non-U.S. Gov't,
Tomography Emission-Computed,
Tomography Emission-Computed Single-Photon,
Tonsil,
pathology.
| Abstract: |
Included in the spectrum of human transmissible spongiform encephalopathies are Creutzfeldt-Jakob disease (CJD) and the new variant form (vCJD), Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia, kuru and various less distinct neuropsychiatric disorders. Progress in our understanding of this group of disorders continues at a prodigious rate, although important vexing practical issues persist. The definitive confirmation of symptomatic prion disease still requires pathological examination, most reliably performed post-mortem. However, paralleling the recent advances in the molecular biological understanding of normal prion protein (PrP(c)) function and the pathophysiology of prion diseases, there have been worthwhile developments in the pre-mortem diagnosis of CJD. Efforts to develop less invasive but very reliable ante-mortem diagnostic tests have received an additional impetus because of the potential epidemic of vCJD. Historically, the ancillary investigation of most merit has been the EEG, whereas the recent advances have encompassed a broader range of technologies, including both magnetic resonance and radioisotopic neuroimaging, and immunoassays for a range of non-specific marker proteins in both CSF, and less commonly, blood. However, given the recent refinement of sophisticated immunoassays, it is envisaged that the pathognomonic, protease-resistant, disease-associated isoforms of the prion protein (PrPres) may soon be directly detectable in the blood and tissues of patients manifesting or incubating a spongiform encephalopathy. |
@ARTICLE{collins:jcn:2000,
AUTHOR = {S Collins and A Boyd and A Fletcher and M F Gonzales and C A McLean and C L Masters},
JOURNAL = {J Clin Neurosci},
TITLE = {Recent advances in the pre-mortem diagnosis of Creutzfeldt-Jakob disease},
YEAR = {2000},
MONTH = {May},
OPTNOTE = {},
NUMBER = {3},
PAGES = {195-202},
VOLUME = {7},
KEYWORDS = {Biological Markers, cerebrospinal fluid, Biopsy, Brain, pathology, Creutzfeldt-Jakob, Diagnosis Differential, Electroencephalography, Human, Magnetic Resonance Imaging, Prions, cerebrospinal fluid, Support Non-U.S. Gov't, Tomography Emission-Computed, Tomography Emission-Computed Single-Photon, Tonsil, pathology},
ABSTRACT = {Included in the spectrum of human transmissible spongiform encephalopathies are Creutzfeldt-Jakob disease (CJD) and the new variant form (vCJD), Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia, kuru and various less distinct neuropsychiatric disorders. Progress in our understanding of this group of disorders continues at a prodigious rate, although important vexing practical issues persist. The definitive confirmation of symptomatic prion disease still requires pathological examination, most reliably performed post-mortem. However, paralleling the recent advances in the molecular biological understanding of normal prion protein (PrP(c)) function and the pathophysiology of prion diseases, there have been worthwhile developments in the pre-mortem diagnosis of CJD. Efforts to develop less invasive but very reliable ante-mortem diagnostic tests have received an additional impetus because of the potential epidemic of vCJD. Historically, the ancillary investigation of most merit has been the EEG, whereas the recent advances have encompassed a broader range of technologies, including both magnetic resonance and radioisotopic neuroimaging, and immunoassays for a range of non-specific marker proteins in both CSF, and less commonly, blood. However, given the recent refinement of sophisticated immunoassays, it is envisaged that the pathognomonic, protease-resistant, disease-associated isoforms of the prion protein (PrPres) may soon be directly detectable in the blood and tissues of patients manifesting or incubating a spongiform encephalopathy.}
}
-
D Dormont.
New variant of Creutzfeldt Jakob disease.
Euro Surveill,
5(9):95-97,
September 2000.
| Abstract: |
Work on experimental pathology carried out for over 10 years indicates that the biological properties of the BSE agent, responsible for the new variant of Creutzfeldt-Jakob disease (vCJD), are particular. In contrast to the situation observed in the other |
@ARTICLE{dormont:es:2000,
AUTHOR = {D Dormont},
JOURNAL = {Euro Surveill},
TITLE = {New variant of Creutzfeldt Jakob disease},
YEAR = {2000},
MONTH = {September},
OPTNOTE = {},
NUMBER = {9},
PAGES = {95-97},
VOLUME = {5},
ABSTRACT = {Work on experimental pathology carried out for over 10 years indicates that the biological properties of the BSE agent, responsible for the new variant of Creutzfeldt-Jakob disease (vCJD), are particular. In contrast to the situation observed in the other}
}
-
S Molloy,
R O'Laoide,
F Brett,
and M Farrell.
The Pulvinar sign in variant Creutzfeldt-Jakob disease.
AJR Am J Roentgenol,
175(2):555-6,
August 2000.
Keywords:
Adult,
Case Report,
Creutzfeldt-Jakob Syndrome,
pathology,
Female,
Human,
Magnetic Resonance Imaging,
Pulvinar,
pathology.
@ARTICLE{molloy:aajr:2000,
AUTHOR = {S Molloy and R O'Laoide and F Brett and M Farrell},
JOURNAL = {AJR Am J Roentgenol},
TITLE = {The "Pulvinar" sign in variant Creutzfeldt-Jakob disease},
YEAR = {2000},
MONTH = {August},
OPTNOTE = {},
NUMBER = {2},
PAGES = {555-6},
VOLUME = {175},
KEYWORDS = {Adult, Case Report, Creutzfeldt-Jakob Syndrome, pathology, Female, Human, Magnetic Resonance Imaging, Pulvinar, pathology}
}
-
C Oppenheim,
J P Brandel,
J J Hauw,
J P Deslys,
and B Fontaine.
MRI and the second French case of vCJD.
Lancet,
356(9225):253-4,
July 2000.
Keywords:
Adult,
Brain Diseases,
diagnosis,
Case Report,
Caudate Nucleus,
pathology,
Corpus Striatum,
pathology,
Creutzfeldt-Jakob Syndrome,
diagnosis,
Fatal Outcome,
Female,
France,
Human,
Image Processing Computer-Assisted,
methods,
Magnetic Resonance Imaging,
methods,
Pulvinar,
pathology,
Putamen,
pathology.
@ARTICLE{oppenheim:lancet:2000,
AUTHOR = {C Oppenheim and J P Brandel and J J Hauw and J P Deslys and B Fontaine},
JOURNAL = {Lancet},
TITLE = {MRI and the second French case of vCJD},
YEAR = {2000},
MONTH = {July},
OPTNOTE = {},
NUMBER = {9225},
PAGES = {253-4},
VOLUME = {356},
KEYWORDS = {Adult, Brain Diseases, diagnosis, Case Report, Caudate Nucleus, pathology, Corpus Striatum, pathology, Creutzfeldt-Jakob Syndrome, diagnosis, Fatal Outcome, Female, France, Human, Image Processing Computer-Assisted, methods, Magnetic Resonance Imaging, methods, Pulvinar, pathology, Putamen, pathology}
}
-
C Poupon,
C A Clark,
V Frouin,
J Regis,
I Bloch,
D Le Bihan,
Bihan D Le,
and J Mangin.
Regularization of diffusion-based direction maps for the tracking of brain white matter fascicles.
Neuroimage,
12(2):184-95,
August 2000.
Keywords:
Algorithms,
Bayes Theorem,
Brain,
anatomy & histology,
Brain Mapping,
methods,
Diffusion,
Human,
Image Processing Computer-Assisted,
Magnetic Resonance Imaging,
statistics & numerical data,
Models Statistical.
| Abstract: |
Magnetic resonance diffusion tensor imaging (DTI) provides information about fiber local directions in brain white matter. This paper addresses inference of the connectivity induced by fascicles made up of numerous fibers from such diffusion data. The usual fascicle tracking idea, which consists of following locally the direction of highest diffusion, is prone to erroneous forks because of problems induced by fiber crossing. In this paper, this difficulty is partly overcomed by the use of a priori knowledge of the low curvature of most of the fascicles. This knowledge is embedded in a model of the bending energy of a spaghetti plate representation of the white matter used to compute a regularized fascicle direction map. A new tracking algorithm is then proposed to highlight putative fascicle trajectories from this direction map. This algorithm takes into account potential fan shaped junctions between fascicles. A study of the tracking behavior according to the influence given to the a priori knowledge is proposed and concrete tracking results obtained with in vivo human brain data are illustrated. These results include putative trajectories of some pyramidal, commissural, and various association fibers. |
@ARTICLE{poupon:neuroimage:2000,
AUTHOR = {C Poupon and C A Clark and V Frouin and J Regis and I Bloch and Le Bihan, D and Bihan D Le and J Mangin},
JOURNAL = {Neuroimage},
TITLE = {Regularization of diffusion-based direction maps for the tracking of brain white matter fascicles},
YEAR = {2000},
MONTH = {August},
OPTNOTE = {},
NUMBER = {2},
PAGES = {184-95},
VOLUME = {12},
KEYWORDS = {Algorithms, Bayes Theorem, Brain, anatomy & histology, Brain Mapping, methods, Diffusion, Human, Image Processing Computer-Assisted, Magnetic Resonance Imaging, statistics & numerical data, Models Statistical},
ABSTRACT = {Magnetic resonance diffusion tensor imaging (DTI) provides information about fiber local directions in brain white matter. This paper addresses inference of the connectivity induced by fascicles made up of numerous fibers from such diffusion data. The usual fascicle tracking idea, which consists of following locally the direction of highest diffusion, is prone to erroneous forks because of problems induced by fiber crossing. In this paper, this difficulty is partly overcomed by the use of a priori knowledge of the low curvature of most of the fascicles. This knowledge is embedded in a model of the bending energy of a spaghetti plate representation of the white matter used to compute a regularized fascicle direction map. A new tracking algorithm is then proposed to highlight putative fascicle trajectories from this direction map. This algorithm takes into account potential fan shaped junctions between fascicles. A study of the tracking behavior according to the influence given to the a priori knowledge is proposed and concrete tracking results obtained with in vivo human brain data are illustrated. These results include putative trajectories of some pyramidal, commissural, and various association fibers.}
}
-
H Urbach.
Creutzfeldt-Jakob disease: analysis of the MRI signal.
Neuroreport,
11(17),
November 2000.
Keywords:
Brain,
pathology,
Creutzfeldt-Jakob Syndrome,
pathology,
Gliosis,
pathology,
Human,
Magnetic Resonance Imaging.
@ARTICLE{urbach:neuroreport:2000,
AUTHOR = {H Urbach},
JOURNAL = {Neuroreport},
TITLE = {Creutzfeldt-Jakob disease: analysis of the MRI signal},
YEAR = {2000},
MONTH = {November},
OPTNOTE = {},
NUMBER = {17},
OPTPAGES = {},
VOLUME = {11},
KEYWORDS = {Brain, pathology, Creutzfeldt-Jakob Syndrome, pathology, Gliosis, pathology, Human, Magnetic Resonance Imaging}
}